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Open Data Set of Human Single Neuron Activity Published

Published: April 15, 2018

Researchers from the Rutishauser lab at Cedars Sinai (M.Faraut, et. al. 2018) have recently published an open data set in the Nature journal Scientific Data. Dr. Rutishauser and his collaborators, Neurosurgeon Adam Mamelak, and Neurologist Jeffrey Chung have helped to pioneer human single-neuron recording techniques. The dataset, includes 1,576 single neurons recorded from the human amygdala and hippocampus from 42 patients with intractable localization-related epilepsy over 65 sessions. This data is representative of 42 individuals who underwent depth electrode monitoring for localization of their seizure focus in preparation for surgical resection. As part of this exercise, recordings were collected using macro-micro electrodes from Ad-Tech Medical, Inc., and data was recorded using the ATLAS system from Neuralynx. Combined with a smaller, previously published data set, they will aid in the study of the neural mechanisms of declarative memory by offering a vast number of human single neuron recordings that are typically difficult to obtain during behavioural tasks.

The group has provided open access to all parts of the data records (stored as Matlab files). To view this open data set, go here: https://datadryad.org//resource/doi:10.5061/dryad.46st5.

For additional information, including usage notes and supplementary information regarding the study specifics, go here: https://www.nature.com/articles/sdata201810.pdf.

Figure 2.
Figure 2.


Figure 2. Electrodes placement and spike sorting and recording quality assessment. (a) Axial (z =− 15) and (b) sagittal (x=25) views of template structural MRI showing electrodes placement for areas of patients in which at least one usable unit was recorded (hippocampus: yellow, amygdala: pink). (c) Histogram of how many units were identified on each active wire (only wires with at least one unit identified are counted). (d–j) Metrics quantifying individual clusters. (d) Histogram of proportion of inter-spike intervals (ISIs) which are shorter than 3 ms. The large majority of clusters had less than 0.5% of such short ISIs. (e) Histogram of mean firing rates. (f) Histogram of CV2 values of all units. (g) Histogram of the SNR of the mean waveform peak of each unit. (h) Histogram of the SNR of the entire waveform of all units. (i) Pairwise distance between all possible pairs of units on all wires where more than 1 cluster was isolated. Distances are expressed in units of s.d. after normalizing the data such that the distribution of waveforms around their mean is equal to 1. (j) Isolation distance of all units for which this metric was defined (n= 1,119, median 31.3).

Rev. 1.0       2018 - 04 - 15