Publications

Functional Architecture of the Rat Parasubiculum
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Researchers at the Berstein Center investigated parasubicular circuits of the rat by anatomical analysis combined with juxtacellular recording/labeling and tetrode recordings during spatial exploration. Anterograde tracing experiments showed that parasubicular neurons extend long “circumcurrent” axons establishing a “global” internal connectivity. The parasubiculum is a prime target of GABAergic and cholinergic medial septal inputs. Other input structures include the subiculum, presubiculum, and anterior thalamus. Functional analysis of identified and unidentified parasubicular neurons shows strong theta rhythmicity of spiking, a large fraction of head-direction selectivity (50%, 34 of 68), and spatial responses (grid, border and irregular spatial cells, 57%, 39 of 68). Parasubicular output preferentially targets patches of calbindin-positive pyramidal neurons in layer 2 of medial entorhinal cortex, which might be relevant for grid cell function. These findings suggest the parasubiculum might shape entorhinal theta rhythmicity and the (dorsoventral) integration of information across grid scales.

Qiusong Tang, Andrea Burgalossi, Christian Laut Ebbesen, Juan Ignacio Sanguinetti-Scheck, Helene Schmidt, John J. Tukker, Robert Naumann, Saikat Ray, Patricia Preston-Ferrer, Dietmar Schmitz, and Michael Brecht

Gamma oscillations coordinate food seeking
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Scientists at the Leibniz-Institut für Molekulare Pharmakologie (FMP) and NeuroCure Cluster of Excellence in Berlin discovered a neuronal circuit which regulates the hypothalamus and activates food-seeking in mice. Surprisingly, this neural mechanism appeared to utilize gamma oscillations, and does not depend on hunger. Optogenetics helped to shed light on the behavioral function of this circuit. The findings allow for better understanding of the mechanisms of feeding behavior, and could lead to development of innovative therapies to treat eating disorders.

Rüdiger Land, Peter Baumhoff, Jochen Tillein, Stephen G. Lomber, Peter Hubka and Andrej Kral

Open Access Cross-Modal Plasticity in Higher-Order Auditory Cortex of Congenitally Deaf Cats Does Not Limit Auditory Responsiveness to Cochlear Implants
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Rüdiger Land, Peter Baumhoff, Jochen Tillein, Stephen G. Lomber, Peter Hubka and Andrej Kral

Layer-specific optogenetic activation of pyramidal neurons causes beta–gamma entrainment of neonatal networks
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Using the Digital Lynx SX in conjunction with Neuronexus optotrodes and Omicron Laser, they established a protocol that combines optogenetics with electrophysiological recordings from neonatal mice in vivo to elucidate the substrate of early network oscillations in the prefrontal cortex.

Sebastian H Bitzenhofer, Joachim Ahlbeck, Amy Wolff, J. Simon Wiegert, Christine E. Gee, Thomas G. Oertner & Ileana L. Hanganu-Opatz

Coupled Oscillations Mediate Directed Interactions between Prefrontal Cortex and Hippocampus of the Neonatal Rat
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Marco D. Brockmann, Beatrice Po schel, Nicole Cichon, and Ileana L. Hanganu-Opatz

Oscillatory Entrainment of Primary Somatosensory Cortex Encodes Visual Control of Tactile Processing
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Kay Sieben, Brigitte Roder, and Ileana L. Hanganu-Opatz

Optical control of hippocampal GABAergic neurons
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Bender AC & Lenck-Santini PP

Hierarchical computation in the canonical auditory cortical circuit
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Craig A. Atencioa, Tatyana O. Sharpeeb, and Christoph E. Schreinera

Receptive field dimensionality increases from the auditory midbrain to cortex
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Craig A. Atencio, Tatyana O. Sharpee, and Christoph E. Schreiner

Spectrotemporal Processing in Spectral Tuning Modules of Cat Primary Auditory Cortex
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Craig A. Atencio*, Christoph E. Schreiner

Inhibition of Protein Kinase M Disrupts the Stable Spatial Discharge of Hippocampal Place Cells in a Familiar Environment
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Jeremy M. Barry, Bruno Rivard, Steven E. Fox, Andre A. Fenton, Todd C. Sacktor, and Robert U. Muller

Chronic multi-electrode neural recording in free-roaming monkeys
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Steven J. Eliades*, XiaoqinWang

Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination
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Petr Znamenskiy & Anthony M. Zador

The dorsomedial striatum encodes net expected return, critical for energizing performance vigor
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Alice Y Wang, Keiji Miura & Naoshige Uchida

Construction of Microdrive Arrays for Chronic Neural Recordings in Awake Behaving Mice
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Eric H. Chang, Stephen A. Frattini, Sergio Robbiati, Patricio T. Huerta